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. 2024 May 7;23:91. doi: 10.1186/s12943-024-01998-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — IGF1R identified as a functional target gene for miR-30a-3p in Osimertinib resistance NSCLC cell. A Schematic representation showing that miR-370-3p specifically binds to IGF1R. RT-qPCR (B) and Western-blot (C) assay were confirmed that IGF1R mRNA and protein expression were significantly upregulated in Osimertinib resistance NSCLC tissues. D Dual-luciferase reporter assay confirmed that miR-30a-3p could competitively targeted wt 3’UTR sequence of IGF1R (HEK-293T). RT-qPCR (E) and Western-blot (F) assay demonstrated that IGF1R mRNA and protein expression were significantly decreased in miR-30a-3p mimic and increased in miR-30a-3p inhibitor group compared with control group. n = 3. *P < 0.05, **P < 0.01, na: no statistical significance. Osimertinib Sensitive; OR: Osimertinib Resistance. RT-qPCR, reverse transcription-quantitative PCR. circ_100696: circ_PPAPDC1A. UTR, untranslated region. Wt, wild type