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. 2024 May 7;23:91. doi: 10.1186/s12943-024-01998-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — circ_PPAPDC1A promotes Osimertinib resistance in NSCLC by regulating the expression of miR-30a-3p. PC9/OR cells were co-transfected with the circ_100696 OE vector and miR-30a-3p mimics. HCC827/OR cells were also co-transfected with sh-circ_100696 and miR-30a-3p inhibitors. A Cell counting kit-8 (CCK8) assay (B) Soft agar colony assay (C) Matrigel invasion and D Annexin V-FITC/PI assay showed the effects of circ_PPAPDC1A/miR-30a-3p axis on cell proliferation, clone formation invasion and apoptosis. circ_PPAPDC1A promoted cell proliferation and invasion while inhibiting cell apoptosis. But these effects were reversed following treatment with miR-30a-3p mimic and mimic inhibitor. n = 3. *P < 0.05, **P < 0.01, na: no statistical significance. Osimertinib Sensitive; OR: Osimertinib Resistance. RT-qPCR, reverse transcription-quantitative PCR. circ_100696: circ_PPAPDC1A. OE: OverExpression