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. 2024 May 7;23:91. doi: 10.1186/s12943-024-01998-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — IGF1R/PI3K/AKT/mTOR pathway can activated by the circ_PPAPDC1A /miR-30a-3p axis. PC9/OR cells were co-transfected with the circ_100696 OE vector and miR-30a-3p mimics. HCC827/OR cells were also co-transfected with sh-circ_100696 and miR-30a-3p inhibitors. RT-qPCR and Western-blot assay analysis of IGF1R mRNA and protein expression (A-B) and (B) PI3K, p-PI3K, AKT, p-AKT, mTOR, p-mTOR protein expression in circ_100696 and miR-30a-3p transfection groups. circ_PPAPDC1A can activate IGF1R/PI3K/AKT/mTOR pathway by regulating the expression of miR-30a-3p, but these effects can be reversed by miR-30a-3p. n = 3. *P < 0.05, **P < 0.01, na: no statistical significance. Osimertinib Sensitive; OR: Osimertinib Resistance. RT-qPCR, reverse transcription-quantitative PCR. circ_100696: circ_PPAPDC1A. OE: OverExpression