Fig. 9.

circ_PPAPDC1A suppresses Osimertinib sensitivity of NSCLC in vivo. A We established subcutaneous tumor models in nude mice via PC9/OR and HCC827/OR cells subcutaneous injection with AZD9291 treatment. After 5 weeks of feeding, the mice were euthanized, and nude mice were taken out to measure their size and weighed. B Xenograft tumor growth curves and C Xenograft tumor weight revealed that circ_PPAPDC1A suppresses Osimertinib sensitivity of NSCLC in in vivo. D The percentage of Ki67-positive cells in xenograft tumors was measured. E TUNEL assay was performed to determine the cell apoptosis rate in Xenograft tumor. n = 3. *P < 0.05, **P < 0.01, na: no statistical significance. Osimertinib Sensitive; OR: Osimertinib Resistance. RT-qPCR, reverse transcription-quantitative PCR. circ_100696: circ_PPAPDC1A. OE: OverExpression