Table 5. Linear mixed-effects models for assessing impact of lesion features on relative difference in SUV metrics.

Model	SUV metric	Fixed effect		beta	std error	t statistic	p-value
V1	SUVmean	Base					ref
		Original SUVmean		−0.636	0.172	−3.71	2.56E-04
		HUmean		0.020	0.014	1.42	0.154
		HUmax		1.20E-04	5.69E-05	2.11	0.035
		Volume		−0.128	0.122	−1.04	0.296
		Location	Bone	6.79	4.99	1.36	0.075
			Other	30.9	17.7	1.75
			Prostate	12.2	6.35	1.92
		PSMARADS	5	−8.20	3.80	−2.16	0.032
	SUVmax	Base					ref
		Original		−0.384	0.101	−3.80	1.78E-04
		HUmean		0.027	0.014	1.85	0.065
		HUmax		0.014	0.006	2.36	0.019
		Volume		−0.141	0.129	−1.10	0.273
		Location	Bone	11.4	5.22	2.19	0.060
			Other	32.1	18.5	1.73
			Prostate	6.38	6.63	0.962
		PSMARADS	5	−10.9	3.97	−2.74	0.007
V2	SUVmean	Base					ref
		Original SUVmean		−0.410	0.190	−2.15	3.20E-02
		HUmean		0.023	0.015	1.55	0.120
		HUmax		0.013	0.006	2.06	0.040
		Volume		−0.134	0.133	−1.01	0.314
		Location	Bone	9.21	5.40	1.71	0.084
			Other	37.9	19.2	1.97
			Prostate	7.47	6.86	1.09
		PSMARADS	5	−9.56	4.13	−2.32	0.021
	SUVmax	Base					ref
		Original		−0.252	0.119	−2.12	3.51E-02
		HUmean		0.019	0.017	1.14	0.253
		HUmax		0.011	0.007	1.53	0.127
		Volume		−0.147	0.149	−0.986	0.324
		Location	Bone	10.4	6.00	1.73	0.059
			Other	39.7	21.4	1.86
			Prostate	−0.313	7.61	−0.411
		PSMARADS	5	−7.92	4.63	−1.71	0.088

Base model: Rel.Diff ~ (1|patient). Evaluated models: Rel.Diff ~ <variable> + (1|patient). Statistical significance relative to base model determined from ANOVA.