| Threatened abortion |
An initial loading dose of up to 40 mg may be given followed by 20 or 30 mg per day until symptoms remit |
| Recurrent pregnancy loss |
10 mg BID until the twentieth week of pregnancy |
| Infertility due to luteal insufficiency |
10 or 20 mg daily starting with the second half of the menstrual cycle until the first day of the next cycle for three consecutive cycles |
| Endometriosis |
10 to 30 mg daily from day 5 to day 25 of the cycle or continuously |
| Irregular cycles |
10 or 20 mg daily starting with the second half of the menstrual cycle until the first day of the next cycle |
| Pre-menstrual syndrome |
10 mg daily starting with the second half of the menstrual cycle until the first day of the next cycle |
| Dysfunctional uterine bleeding |
When treatment is started to arrest a bleeding episode, 20 or 30 mg dydrogesterone per day is to be given for up to 10 days. For continuous treatment, 10 or 20 mg dydrogesterone per day should be given during the second half of the menstrual cycle. |
| Secondary amenorrhea |
10 or 20 mg dydrogesterone per day, to be given daily for 14 days during the second half of the theoretical menstrual cycle to produce an optimum secretory transformation of an endometrium that has been adequately primed with either endogenous or exogenous estrogen |
| Hormone replacement therapy |
-
–
Continuous sequential therapy: An estrogen is dosed continuously and one tablet of 10 mg dydrogesterone is added for the last 14 days of every 28 day cycle, in a sequential manner.
-
–
Cyclic therapy: When an estrogen is dosed cyclically with a treatment-free interval, usually 21 days on and 7 days off. One tablet of 10 mg dydrogesterone is added for the last 12 -14 days of estrogen therapy.
-
–
Depending on the clinical response, the dosage can subsequently be adjusted to 20 mg dydrogesterone per day.
|
