Table 3.
Efficacy outcomes.
| Propofol (N = 44) | Ciprofol (N = 90) | Effect size (95% CI)a | P-value | |
|---|---|---|---|---|
| Primary outcome | ||||
| Success rate of anesthesiab | 44 (100.0) | 90 (100.0) | Rate difference = 0.0 (−4.1 to 8.0) | >0.999 |
| Secondary outcomes | ||||
| Time to successful induction (sec)c | 60 [52, 60] | 60 [60, 63] | Median difference = 2 (1 to 7) | <0.001 |
| Time to full awake (min)d | 7.7 [6.4, 9.1] | 10.0 [8.5, 11.7] | Median difference = 2.3 (1.4 to 3.1) | <0.001 |
| Time to PACU discharge (min)e | 11.6 [10.4, 13.1] | 14.1 [12.5, 15.7] | Median difference = 2.3 (1.5 to 3.2) | <0.001 |
| Satisfaction scores (score) f | ||||
| Patients | 10 [10, 10] [6, 10] | 10 [10, 10] [6, 10] | Median difference = 0 (0 to 0) | 0.011 |
| Anesthesiologists | 12 [11, 12] [6, 12] | 12 [11, 12] [4, 12] | Median difference = 0 (0 to 0) | 0.872 |
| Surgeons | 12 [12, 12] [8, 12] | 12 [12, 12] [5, 12] | Median difference = 0 (0 to 0) | 0.286 |
| Dissatisfaction g | ||||
| Patients | 7 (15.9) | 3 (3.3) | Relative risk = 0.21 (0.06 to 0.77) | 0.024 |
| Anesthesiologists | 13 (29.5) | 23 (25.6) | Relative risk = 0.87 (0.49 to 1.54) | 0.625 |
| Surgeons | 6 (13.6) | 19 (21.1) | Relative risk = 1.55 (0.67 to 3.60) | 0.297 |
| Exploratory outcomes | ||||
| Mean arterial pressure (mmHg)h | 79 (4) | 83 (4) | Median difference = 4 (2 to 5) | <0.001 |
| Heart rate (bpm)h | 71 (3) | 70 (3) | Median difference = −1 (−3 to 0) | 0.149 |
| Pulse oxygen saturation (%)h | 97 [96, 97] [94, 98] | 97 [96, 97] [95, 98] | Median difference = 0 (0 to 1) | 0.097 |
Data are mean (standard deviation), median [interquartile range] [full range] or n (%). CI, confidence interval; PACU, post-anesthesia care unit. P values in bold indicate statistical differences between the two groups.
Calculated as ciprofol group vs. or minus propofol group.
Defined as the completement of surgery without anesthetic remedy.
Defined as the duration from the first administration of the study drugs to the first Modified Observer’s Assessment of Alertness and Sedation (MOAA/S, a 6-point scale where 5 = alert and 0 = no responsiveness) score ≤1.
Defined as the duration from the last administration of the study drugs to completely awaking, indicated by the first MOAA/S = 5 in three consecutive times of MOAA/S = 5 assessments.
Defined as the duration from the last administration of the study drugs to departure, indicated by the first Aldrete score ≥9 in three consecutive times of Aldrete score assessments.
Scores ranges from 0 (least satisfied) to 10 (fully satisfied) as for patients and ranges from 0 (least satisfied) to 12 (fully satisfied) as for anesthesiologists and surgeons.
Satisfaction score <10 for patients and <12 for anesthesiologists and surgeons.
Average value from the first administration of study drugs until awake from anesthesia.