Chemical structure and characteristics of the APIs that formed DESs with CA along with CA and MC structures.
| API | Structure | pKa | Solubilitya | T m (°C) | Medical uses | Ref. |
|---|---|---|---|---|---|---|
| Risperidone |
|
8.76 | 2.16 | 171 (ref. 28) | Treatment of schizophrenia, bipolar mania and psychosis | 29 |
| Fentanyl |
|
8.99 (ref. 30) | 0.2 | 83–84 | Opioid analgesic for pain management | 30 and 31 |
| Levofloxacin |
|
Basic pKa 8.12 and acidic pKa 6.1 | Sparingly soluble | 225–227 | Broad-spectrum antibacterial drug | 25, 32 and 33 |
| Droperidol (Drp) |
|
7.46 | 4.21 | 145–146.5 | Management of the nausea and vomiting in surgical and diagnostic procedures | 34 and 35 |
| Aripiprazole (Arp) |
|
7.6 | 0.045 | 137–140 | Treatment of many forms of mood and psychotic disorders | 36 |
| Capric acid (CA) |
|
4.9 | 0.062 | 31.5 | — | 37 |
| Methyl caprate (MC) |
|
— | 0.004b | −18.0 | — | 38 |
a
Aqueous solubility at 25 °C, all records were obtained from PubChem.27
b
Solubility at 20 °C. Tm (melting point).