Figure 8.

AKAP12 gene and protein expression are upregulated in human failing hearts. A, Summary plot of AKAP12 gene expression data that was generated from a previous report of 16 meta-studies,²⁵ each point represents average expression from 1 study represented as t-value resulting from the individual differential expression analysis. B, Quantification of AKAP12 gene expression in left ventricular (LV) samples collected from patients with failing hearts; n=8 and nonfailing hearts; n=6. C, Western blot of AKAP12 including all LV samples collected from patient failing and nonfailing hearts. D, Quantification of the Western blot failing hearts; n=8 and nonfailing hearts; n=6. All data represented as average mean±SEM. Data were determined to have a parametric distribution by the Shapiro-Wilk test; α=0.05 and were analyzed using unpaired 2-tailed Student t test for all panels.