Figure 2. Nanobody epitope groups and mAb epitope classes mapped on receptor-binding domain (RBD).

(A) Nanobody epitope groups overlapping with the three mAb epitope classes (classes 1, 2, and 3). Nanobody groups are highlighted in gold, while mAb class footprints are outlined in black. mAb epitopes are taken from Cox et al. (B) A single RBD subunit with the angiotensin-converting enzyme 2 (ACE2) footprint/RBM mapped in green. All epitopes are represented on the structure of wild-type RBD (PDB ID: 6M0J). All structure representations were generated using ChimeraX (Pettersen et al.).