Table 1. Numbers of known aging-associated genes (AAGs) reported in the scientific literature to affect (increase/decrease chronological lifespan [CLS]/replicative lifespan [RLS]) under a variety of conditions.

The gene lists were extracted, after processing, from downloaded files (as of November 8, 2022) using the databases SGD (Engel et al., 2022) and GenAge (Townes et al., 2020). The actual gene lists are available in Figure 1—source data 1. The signs ‘+’ and ‘−’ indicate that the respective annotation property is present or missing in that group of genes. We present the total number of genes in each category as the number of, as a trend, severely understudied/uncharacterized genes among those. The columns ‘RUG’ and ‘RDG’ show the numbers of rapamycin-up- and -downregulated genes in each of the 15 categories.

Category	CLS increase	CLS decrease	RLS increase	RLS decrease	Number of genes	Understudied genes	RUG	RDG
1	+	−	−	−	328	20	68	62
2	−	+	−	−	615	22	108	73
3	−	−	+	−	349	19	73	64
4	−	−	−	+	318	15	43	56
5	+	+	−	−	108	0	17	18
6	+	−	+	−	72	2	12	26
7	+	−	−	+	72	3	9	18
8	−	+	+	−	120	3	14	28
9	−	+	−	+	180	0	24	34
10	−	−	+	+	59	0	8	14
11	+	+	+	−	29	1	7	7
12	+	+	−	+	45	1	7	9
13	+	−	+	+	30	1	2	11
14	−	+	+	+	55	1	5	11
15	+	+	+	+	19	0	0	2