Table 1. Characteristics of the total patients and comparison of the patients according to the presence of postoperative CSF leak.
| Total | Postoperative CSF | |||||||
|---|---|---|---|---|---|---|---|---|
| Leak (–) | Leak (+) | |||||||
| n | (%) | n | (%) | n | (%) | p | ||
| Age groups at surgery (y) | 15–34 | 25 | (14.7) | 20 | (80.0) | 5 | (20.0) | |
| 35+ | 145 | (85.3) | 139 | (95.9) | 6 | (4.1) | 0.003 | |
| Gender | Female | 90 | (52.9) | 84 | (93.3) | 6 | (6.7) | |
| Male | 80 | (47.1) | 75 | (93.8) | 5 | (6.3) | 0.912 | |
| Diabetes mellitus | No | 112 | (65.9) | 108 | (96.4) | 4 | (3.6) | |
| Yes | 58 | (34.1) | 51 | (87.9) | 7 | (12.1) | 0.033 | |
| Preoperative symptoms | Swollen hands and feet | 33 | (19.4) | 31 | (93.9) | 2 | (6.1) | |
| Visual impairment | 54 | (31.8) | 52 | (96.3) | 2 | (3.7) | ||
| Sexual dysfunction | 15 | (8.8) | 14 | (93.3) | 1 | (6.7) | ||
| Other | 68 | (40.0) | 62 | (91.2) | 6 | (8.8) | 0.726 | |
| Intraoperative CSF leak | No | 142 | (83.5) | 132 | (94.3) | 8 | (5.7) | |
| Yes | 28 | (16.5) | 27 | (90.0) | 3 | (10.0) | 0.387 | |
| Suprasellar extension | No | 65 | (38.2) | 62 | (95.4) | 3 | (4.6) | |
| Yes | 105 | (61.8) | 97 | (92.4) | 8 | (7.6) | 0.439 | |
| Adenoma size | Microadenoma | 18 | (10.6) | 17 | (94.4) | 1 | (5.6) | |
| Macroadenoma | 127 | (74.7) | 119 | (93.7) | 8 | (6.3) | ||
| Giant adenoma | 25 | (14.7) | 23 | (92.0) | 2 | (8.0) | 0.938 | |
| Pseudocapsule invasion | No | 146 | (85.9) | 136 | (93.2) | 10 | (6.8) | |
| Yes | 24 | (14.1) | 23 | (95.8) | 1 | (4.2) | 0.621 | |
| Knosp score | 0–1 | 72 | (42.4) | 69 | (95.8) | 3 | (4.2) | |
| 2 + | 98 | (57.6) | 90 | (91.8) | 8 | (8.2) | 0.295 | |
| Hardy class | 0–2 | 84 | (49.4) | 80 | (95.2) | 4 | (4.8) | |
| 3+ | 86 | (50.6) | 79 | (91.9) | 7 | (8.1) | 0.371 | |
| Resection rate | Subtotal | 46 | (27.1) | 45 | (97.8) | 1 | (2.2) | |
| Total | 124 | (72.9) | 114 | (91.9) | 10 | (8.1) | 0.165 | |
| Postoperative complication | No | 144 | (84.7) | 138 | (95.8) | 6 | (4.2) | |
| Yes | 26 | (15.3) | 21 | (80.8) | 5 | (19.2) | 0.004 | |
| Cutoff for tumor volume | < 7.5 cm 3 | 122 | (71.8) | 120 | (98.4) | 2 | (1.6) | |
| ≥ 7.5 cm 3 | 48 | (28.2) | 39 | (81.3) | 9 | (18.8) | 0.001 | |
| Tumor volume | Median (min-max) | 2.5 | (1–30) | 8.5 | (5.0–20.9) | 2.7 | (1–30) | 0.001 |
| Median hospital stay (d) | Median (min-max) | 7 | (3–68) | 25 | (10.0–54) | 7 | (3–68) | 0.001 |
| Follow-up duration (mo) | Median (min-max) | 50 | (1–100) | 30 | (9.0–78) | 50 | (1–100) | 0.756 |
Abbreviation: CSF, cerebrospinal fluid.