Table 2.
Comparison of patient characteristics and clinical data between the acute and lymphoma ATLL subtypes
| Characteristic | Acute (N=79) | Lymphoma (N=34) | χ2 | P value |
|---|---|---|---|---|
| Age at onset | 0.073 | 0.787 | ||
| ≤60 (years) | 49 (62.0) | 22 (64.7) | ||
| >60 (years) | 30 (38.0) | 12 (35.3) | ||
| Gender | 0.521 | 0.471 | ||
| Male | 43 (54.4) | 21 (61.8) | ||
| Female | 36 (45.6) | 13 (38.2) | ||
| Laboratory values | ||||
| Leukocytosis | 67 (84.8) | 4 (11.8) | 0.000* | |
| Lymphocytosis | 64 (81.0) | 0 | 0.000* | |
| Anemia | 23 (29.1) | 5 (14.7) | 2.647 | 0.104 |
| Thrombocytopenia | 23 (29.1) | 5 (14.7) | 2.647 | 0.104 |
| Hypercalcemia | 35 (44.3) | 10 (29.4) | 2.200 | 0.138 |
| LDH elevated | 75 (94.9) | 27 (79.4) | 6.520 | 0.011 |
| LDH≥2× normal | 47 (59.5) | 16 (47.1) | 1.490 | 0.222 |
| Hypoalbuminemia | 42 (53.2) | 9 (26.5) | 6.840 | 0.009 |
| Organ involvement | ||||
| Lymphadenopathy | 60 (75.9) | 34 (100) | 9.830 | 0.002 |
| Bone marrow | 67 (84.8) | 11 (32.4) | 30.594 | 0.000 |
| Bone | 6 (7.6) | 5 (14.7) | 1.368 | 0.242 |
| Hepatomegaly | 25 (31.6) | 4 (11.8) | 0.034 | |
| Splenomegaly | 41 (51.9) | 15 (44.1) | 0.576 | 0.448 |
| Skin | 18 (22.8) | 5 (14.7) | 0.957 | 0.328 |
| Lung | 4 (5.1) | 2 (5.9) | 1.000* | |
| CNS | 1 (1.3) | 0 | 1.000* | |
| Overall survival, months (median) | 2.2 (1.779-2.688) | 8.7 (7.74-9.726) | 13.552 | 0.000 |
*
Fisher’s exact test.
LDH, Lactate dehydrogenase; CNS, Central nervous system.