Table 1.

Markers and functions of tams in different tumor tissues

Types of cancer	TAMs markers	TAMs Function	References
Breast cancer	CD68-Pan macrophages CD11c-M1 HLA-DRα-M1 CD163-M2 CD206-M2 MMP9-M2	CD68 + TAMs are an independent predictor of reduced overall survival (OS) and relapse-free survival (RFS) CD163 + TAMs are positively associated with poor histological grade, larger tumor size, and lymph node (LN) metastasis	(Sousa et al. 2015; Riabov et al. 2016;Koru-Sengul et al. 2016; Tiainen et al. 2015; DeNardo et al. 2011; Gordon and Pluddemann 2017)
Colorectal cancer	CD68-M1 NOS2-M1 CD163-M2 CD206-M2	CD68 + TAMs are associated with high patient survival CD163 + TAMs suggest earlier local recurrence and poorer survival NOS2 + TAMs are significantly associated with improved cancer-specific survival (CSS)	(Edin et al. 2012; Nakayama et al. 2002; Sickert et al. 2005; Cavnar et al. 2017; Shabo et al. 2009)
Non-small cell lung cancer	CD68-Pan macrophages HLA-DR-M1 iNOS-M1 pSTAT1-M1 CD163-M2 CD204-M2 MACRO-M2	CD68 + TAMs correlated with a higher TNM stage, peritumoral lymphatic vessel density (LVD), and LN metastasis CD163 + TAMs accumulation is strongly associated with reduced progression-free survival (PFS) CD204 + TAMs correlated with tumor differentiation, pathologic stage, T status, nodal involvement, lymphatic permeation, vessel invasion, and pleural invasion MACRO + TAMs contribute to an immunosuppressive mechanism protecting cancer cells	(Almatroodi et al. 2016; Rakaee et al. 2019; Zhang et al. 2011; Yusen et al. 2018; Li et al. 2018; Yang et al. 2015; La Fleur et al. 2018)
Ovarian cancer	CD68-Pan macrophages CD80-M1 CD163-M2	CD68 + TAMs are significantly associated with lower OS CD163 + TAMs are negative predictors of PFS and OS	(Lan et al. 2013; No et al. 2013; Yin et al. 2016)
Prostate cancer	CD68-Pan macrophages YKL40-M1 CD163-M2	CD68 + TAMs are associated with TNM clinical stage and are predictors of shorter CSS CD163 + TAMs are associated with a higher incidence of metastasis and a lower incidence of CSS	(Lundholm et al. 2015; Takayama et al. 2009)