Table 3.

Interaction Effects Cooling Agent with Base Flavor, Nicotine Concentration, and Nicotine/Tobacco Use on Appeal and Sensory Attributes

	Appeal						Sensory attributes
	Liking		Disliking		Use again		Sweetness		Smoothness		Bitterness		Harshness		Coolness
	F	P	F	P	F	P	F	P	F	P	F	P	F	P	F	P
Cooling agenta × Flavorb	0.1	0.993	0.1	0.993	0.3	0.976	0.1	0.993	0.5	0.771	0.9	0.688	2.5	0.067	1.1	0.470
Cooling agenta × Nicotine Concentrationc	0.1	0.996	0.0	0.996	0.0	0.996	0.5	0.791	0.4	0.905	0.0	0.996	0.0	0.996	1.7	0.273
Cooling agenta × Nicotine/tobacco used	0.2	0.968	0.9	0.795	1.0	0.760	0.2	0.968	0.1	0.968	0.3	0.968	0.5	0.968	1.7	0.383
Cooling agenta × Pre-existing menthol/mint flavor preferencee	1.2	0.484	0.5	0.778	1.3	0.484	0.3	0.854	1.6	0.484	0.3	0.854	1.4	0.484	4.0	0.062

Note. p = p-value corrected for multiple testing to control false-discovery rate <.05 from omnibus F tests.

^aNo cooling agent vs. menthol vs. synthetic cooling agent WS-23.

^bTobacco vs. mint vs. fruit.

^c2% vs. 4%.

^dCurrent exclusive combustible cigarette use vs. exclusive e-cigarette use vs. dual use of cigarettes and e-cigarettes.

^eMenthol as usually used flavor among cigarette smokers and menthol or mint as most often used flavors among e-cigarette users.