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Viability of proximal tubule epithelial cells (PTECs) in human kidney 3D MPS.
Images demonstrate minimal increase in histologic cell death/injury or gross morphology with 50 μg/mL of polymyxin E treatment at 72 hours. Thus, transcriptomic signatures are early markers of PTEC injury. (A) Control MPS and (B) Polymyxin-E treated MPS live/dead staining (calcein AM and ethidium bromide, respectively). Scale bar is 100 micrometers
