Table 3.
Previously identified variants that were replicated in this study (association with relevant APO P < 0.05).
| APO | rsID | OR (se) | P-value | Direction | Sample size | Mapped gene |
|---|---|---|---|---|---|---|
| Gestational length (EFO_0003917) | rs7093347 | 0.17 (0.05) | 0.001749 | + + + | 4646 | ADAMTS14 |
| rs2963463 | − 0.13 (0.05) | 0.005615 | –- | 4646 | EBF1, LINC02227 | |
| rs113018921 | 0.24 (0.11) | 0.025633 | + + - | 4646 | MSI2 | |
| rs55889542 | 0.19 (0.09) | 0.028307 | + + + | 4646 | KAZN | |
| Preeclampsia (EFO_0000668) | rs4655789 | 1.36 (0.15) | 0.012197 | +—+ | 7480 | WLS |
| rs9663238 | 0.74 (0.06) | 0.001554 | –- | 7366 | HKDC1 | |
| GDM (EFO_0004593) | rs36090025 | 1.30 (0.11) | 0.005257 | + + + | 7366 | TCF7L2 |
| rs10830962 | 1.28 (0.10) | 0.005672 | +—+ | 7366 | MTNR1B, SNRPGP16 | |
| rs9275373 | 1.34 (0.15) | 0.0163 | + + + | 7366 | HLA-DQB1, MTCO3P1 | |
| Pregnancy loss (EFO_0006923) | rs12406463 | 1.58 (0.22) | 0.005194 | + + ? | 6855 | LINC01717 |
The odds ratio (OR; standard error in parentheses), significance (P-value), and direction of the effect are shown for the meta-analysis of three sub-populations, as well as the closest gene(s) to the relevant marker.