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. 2024 May 7;15:3804. doi: 10.1038/s41467-024-47460-9

Fig. 5. Dose response for PA, MMA, and PKU in adult participants.

Fig. 5

a Predicted relationship between mRNA-3927 dose and plasma 2-MC levels at steady state after Q3W dosing. b Predicted relationship between mRNA-3705 dose and plasma methylmalonic acid levels at steady state after Q2W dosing. c Predicted relationship between mRNA-3210 dose and blood Phe levels at steady state after weekly dosing. Solid lines represent the pre-dose levels at steady state (median). Shaded regions represent the 95% prediction interval. 2-MC 2-methylcitrate, MMA methylmalonic acidemia, mRNA messenger RNA, PA propionic acidemia, Phe phenylalanine, PKU phenylketonuria, Q2W every 2 weeks, Q3W every 3 weeks, QW every week. Source data are provided as a Source Data file.