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. 2024 Apr 24;15:1355405. doi: 10.3389/fimmu.2024.1355405

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Copyright © 2024 Barrios, Leary, Darden, Rincon, Willis, Polcz, Gillies, Munley, Dirain, Ungaro, Nacionales, Gauthier, Larson, Morel, Loftus, Mohr, Maile, Kladde, Mathews, Brusko, Brusko, Moldawer, Bacher and Efron

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Differences in PMN-, E-, and M-MDSCs across septic time-points. (A) Cell dynamic parameters estimated from CellRank were compared across cells from septic patients at Day 4 ± 1 (acute sepsis) (n=4), patients at day 14-21 who rapidly recovered (“RAP”) (n=4), and patients at day 14-21 who developed chronic critical illness (“CCI”) (n=5) in M-MDSCs. (B, C) Similar to (A) for PMN-MDSCs and E-MDSCs, respectively. Significant p-values (< 0.05) were obtained from fitting a linear mixed model. E, early; PMN, granulocytic; H, hybrid; M, monocytic.