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. 2024 Apr 24;15:1384198. doi: 10.3389/fphar.2024.1384198

TABLE 2.

Linear regression model was performed using the backpropagation method, excluding variables from the model that do not have a significant impact on the variance explained in the levels of IGFBP-7 and MIP-1β.

IGFBP-7 plasma levels (ng/mL)
Predictors F (df1, df2) R p-value β SD p-value
Model 1 2.93 (2, 39) 0.137 0.066 51.35 89.95 0.572
Group 72.24 30.59 0.024
Age 0.38 1.79 0.831
Model 2 5.97 (1, 39) 0.136 0.019 70.09 21.16 0.002
Group 73.12 29.93 0.019
MIP-1β plasma levels (pg/mL)
Model 1 4.02 (2, 39) 0.178 0.026 −78.54 89.95 0.190
Group 31.17 20.01 0.128
Age 2.50 1.17 0.039
Model 2 5.41 (1, 39) 0.125 0.026 −75.22 59.90 0.217
Age 2.75 1.18 0.026

Df1, degrees of freedom of the independent variables; df2, degrees of freedom of the dependent variable; R2, R-squared; p-value, p-value of the regression equation of each model; β, beta coefficient; SD, standard deviation of the beta coefficients; p = p-value of the beta coefficients. The group is a dichotomic variable formed from mental conditions (controls, bipolar disorder). Age is a continuous variable. IGFBP, insulin-like growth factor-binding protein; MIP-1β, macrophage inflammatory protein 1 beta.