. 2024 Apr 24;15:1384198. doi: 10.3389/fphar.2024.1384198

TABLE 4.

Spearman’s correlation coefficient was the main correlation coefficient used.

Proteins	Groups	MCP-1 (pg/mL)		MIP-1β (pg/mL)		TNF-α (pg/mL)
Proteins	Groups	r	p	r	p	r	p
IGF-2 (ng/mL)	All	0.043	0.791	0.188	0.244	−0.063	0.701
	C	0.176	0.458	0.402	0.079	−0.298	0.202
	BD	−0.183	0.439	0.006	0.98	0.171^P	0.471
	BD0	0.224	0.533	0.262^P	0.464	0.240^P	0.504
	BD1	−0.234^P	0.516	−0.067	0.855	0.203^P	0.575
IGFBP-1 (ng/mL)	All	0.463**	0.003	0.148	0.362	0.043	0.793
	C	0.572**	0.008	0.010^P	0.965	0.045^P	0.850
	BD	0.377	0.101	0.129	0.587	−0.153^P	0.519
	BD0	0.139	0.701	0.212^P	0.556	−0.174^P	0.631
	BD1	0.247^P	0.492	0.127	0.726	−0.052^P	0.866
IGFBP-3 (ng/mL)	All	−0.444**	0.004	−0.127	0.435	−0.186	0.251
	C	−0.310	0.184	0.267^P	0.256	−0.221^P	0.349
	BD	−0.087	0.715	0.131	0.582	0.028^P	0.907
	BD0	0.176	0.627	0.209^P	0.563	−0.176^P	0.626
	BD1	−0.639* ^P	0.047	0.273	0.446	−0.121^P	0.740
IGFBP-5 (ng/mL)	All	−0.314*	0.048	−0.272	0.089	−0.290	0.069
	C	−0.177	0.456	−0.058^P	0.809	−0.374^P	0.104
	BD	0.275	0.240	−0.023	0.925	−0.169^P	0.477
	BD0	0.152	0.676	0.414^P	0.234	−0.023^P	0.949
	BD1	−0.459^P	0.182	−0.115	0.751	−0.300^P	0.400
IGFBP-7 (ng/mL)	All	0.124	0.447	0.313*	0.049	−0.120	0.462
	C	0.197	0.405	0.312^P	0.181	−0.386^P	0.093
	BD	−0.059	0.806	0.260	0.268	−0.056	0.816
	BD0	−0.055	0.881	0.273	0.446	0.479	0.162
	BD1	−0.310^P	0.384	0.018	0.960	−0.074^P	0.839

r, coefficient values range from −1 to 1. ^PPearson’s correlation coefficient was used when both distributions adjust to a normal distribution (Shapiro–Wilk test; p-value ˃ 0.05). All (n = 40), C + BD groups; C (n = 20), control group; BD (n = 20), bipolar disorder; BD0 (n = 10), bipolar disorder time 0 (before treatment at hospital admission in the longitudinal subgroup); BD1 (n = 10), bipolar disorder time 1 (after treatment at hospital admission in the longitudinal subgroup); IGF, insulin-like growth factor; IGFBP, insulin-like growth factor-binding protein; MCP-1, monocyte chemoattractant protein 1; MIP-1β, macrophage inflammatory protein 1 beta; TNF-α, tumor necrosis factor alpha. * p-value <0.05 and ** p-value <0.01.