FIGURE 2.

Morphology of the studied nanocomplexes and cytotoxicity on human glioma stem cells (GSCs) and corresponding radioresistance (GSCs-RR). (A) Scanning electron microscope images of diethyldithiocarbamate (DE)-Cu₄O₃ NPs, DE-Cu₂O NPs, and DE-FeO NPs (Magnification ×5,000). (B) Growth inhibition potentials of standard chemotherapy (temozolomide, TMZ), DE, metal oxides (Cu₄O₃ NPs, Cu₂O NPs, and FeO NPs), and nanocomplexes (DE-Cu₄O₃ NPs, DE-Cu₂O NPs, and DE-FeO NPs) as shown by (I,II) dose response curves and (III,IV) half maximal inhibitory concentration (IC₅₀) values for MGG18 and JX39P, respectively. (C) Growth inhibition potentials of these above-mentioned compounds on MGG18-RR and JX39P-RT as demonstrated by (I,II) dose response curves and (III,IV) IC₅₀. Data are demonstrated as mean ± SEM. DE-FeO NPs nanocomplex was compared to other compounds. Values are considered statistically significant at p < 0.05*, <0.01**, and <0.001***.