FIGURE 3.

Cytotoxicity on mouse glioma stem cells (GSCs) and correlative radioresistance GSCs-RR. (A) Growth inhibition impacts of standard chemotherapy (temozolomide, TMZ), diethyldithiocarbamate (DE), metal oxides nanoparticles (Cu₄O₃ NPs, Cu₂O NPs, and FeO NPs), and nanocomplexes (DE-Cu₄O₃ NPs, DE-Cu₂O NPs, and DE-FeO NPs), as illustrated by (I,II) dose response curves and (III,IV) half maximal inhibitory concentration (IC₅₀) values for GS and platelet derived growth factor-induced glioma stem cells (PDGF-GSC), respectively. (B) Growth inhibition potentials of these compounds on GSRR and PDGF-GSC-RR as presented by (I,II) dose response curves and (III,IV) IC₅₀. Data are demonstrated as mean ± SEM. DE-FeO NPs nanocomplex was compared to other compounds. Values are considered statistically significant at p < 0.05*, <0.01**, and <0.001***.