FIGURE 7.

Repressive potentials of standard chemotherapy and the most active nanocomplex on stemness gene expression of human and mouse glioma stem cells (GSCs) and radioresistance GSCs-RR. Relative fold decrement in gene expression of (A) aldehyde dehydrogenase (ALDH)1A1, ATP-binding cassette (ABC)B1, ABCC1, ABCG2, CD44, CD133 (PROM1), NOTCH1, and β-catenin (CTNNB1) as well as (B) NANOG, OCT-4, SOX-2, nestin, epidermal growth factor receptor (EGFR), O⁶-methylguanine-DNA methyltransferase (MGMT), hypoxia inducing factor (HIF1A), and ZEB1 in (I) human MGG18, (II) mouse GS, (III) MGG18-RR, and (IV) GSRR after treatment with temozolomide (TMZ) and diethyldithiocarbamate (DE)-FeO NPs. Data are demonstrated as mean ± SEM. DE-FeO NPs nanocomplex was compared to TMZ. Values are considered statistically significant at p < 0.05*, <0.01**, and <0.001***.