Table 3.

Adverse events

Toxicity, n (%)	Grade 1	Grade 2	Grade 3	Grade 4
Myelosuppression	17 (12.9)	13 (9.8)	6 (4.5)	6 (4.5)
Nausea	6 (4.5)	1 (0.8)	0	0
Vomiting	9 (6.8)	2 (1.5)	0	0
ALT/AST	0	2 (1.5)	1 (0.8)	0
Neurotoxicity
Limb	3 (2.3)	2 (1.5)	2 (1.5)	0
Back pain	4 (3.0)	1 (0.8)	0	0
Paralysis	2 (1.5)	2 (1.5)	0	0
Headache	0	5 (3.8)	1 (0.8)	0
Mucositis	0	1 (0.8)	1 (0.8)	0
Leukoencephalopathy	10 (7.6)	0	0	0
Acute cerebral meningitis	0	0	0	0

ALT, alanine aminotransferase; AST, aspartate aminotransferase.