Figure 2.

Claudin-4 Expression of Urothelial Carcinoma of the Urinary Bladder among Studied Cases (a) Low-grade papillary urothelial carcinoma, showing moderate cytoplasmic and membranous Claudin-4 immunostaining of more than 50% of tumor cells, considered as high Claudin-4 expression (score 6) (x400 original magnification). (b) Low-grade papillary urothelial carcinoma, showing strong cytoplasmic and membranous Claudin-4 immunostaining of more than 50% of tumor cells, considered as high Claudin-4 expression (score 9) (x400 original magnification). (c) High-grade invasive urothelial carcinoma infiltrating fat, showing weak cytoplasmic and membranous Claudin-4 immunostaining of 25-50% of tumor cells, considered as low Claudin-4 expression (score 2) (x200 original magnification). (d) High-grade invasive urothelial carcinoma infiltrating fat, showing weak cytoplasmic and membranous Claudin-4 immunostaining of more than 50% of tumor cells, considered as high Claudin-4 expression (score 3 ) (x400 original magnification). (e) High-grade invasive urothelial carcinoma, showing strong cytoplasmic and membranous Claudin-4 immunostaining of more than 50% of tumor cells, considered as high Claudin-4 expression (score 9) (x400 original magnification)