Fig. 5.

In vivo antitumor activity of Oxa/HMI Gel on orthotopic colorectal tumor-bearing Balb/c mice. In vivo bioluminescence images (A) and corresponding quantification (B) of orthotopic colorectal tumor-bearing mice receiving various treatments (PBS, HM NPs, Inulin Gel, Oxa@HM NPs, and Oxa@HMI Gel) at 0, 7, and 14 d (n = 3). (C) Representative images of colon tumors excised from the sacrificed tumor-bearing mice. Red circles indicated for colorectal tumor regions. Tumor weight (D) and body weight (E) of orthotopic colorectal tumor-bearing mice after various treatments (n = 3). (F) Histological analysis by H&E, Ki-67, and TUNEL staining of tumor sections after various treatments. Scale bar: 20 μm. The data are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.