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. 2024 May 8;7:0364. doi: 10.34133/research.0364

Fig. 8.

Fig. 8.

The tumor immune microenvironment modulation by Oxa@HMI Gel via regulating intratumoral microbiota on orthotopic colorectal tumor-bearing Balb/c mice. (A) Schematic diagram of tumor immune microenvironment modulation by Oxa@HMI Gel via regulating intratumoral microbiota. (B) Immunohistochemical analysis of ID2 and IL-12 receptors on T cells in TME of orthotopic colorectal tumor-bearing mice after various treatments. Scale bar: 50 μm. Representative flow cytometric images (C) and corresponding quantitative analysis of CD8+ T cells (D) and CD4+ T cells (E) infiltrated in the tumor tissues form mice after different treatments (n = 3). (F) Immunofluorescent staining images of CD8+ T cells and CD4+ T cells in tumor tissues from mice after various treatments. Scale bar: 20 μm. (G) The secretion levels of serum IFN-γ determined by enzyme-linked immunosorbent assay (n = 3). The data are presented as the mean ± SD. *P < 0.05, **P < 0.01.