Table 2.
Transmission blocking vaccine candidates currently under preclinical development or in clinical trials.
| Immunogen | Vaccine type | Current status | Adjuvant | ClinicalTrials.gov ID | References | |
|---|---|---|---|---|---|---|
| Pfs48/45 | - | Subunit | Preclinical | - | - | |
| Pfs230 | Pfs230D1M-EPA | Subunit | Phase II | Alhydrogel® | NCT02334462 | [2,10,44] |
| Pfs230D1M-EPA | AS01 | NCT02942277 | ||||
| Pfs230D1M-EPA | AS01 | NCT03917654 | ||||
| Pfs25 | Pfs25M-EPA | Subunit | Phase I | Alhydrogel® | NCT02334462 | [2,6,9] |
| Plant-Derived Pfs25 VLP-FhCMB | Alhydrogel® | NCT02013687 | ||||
| Pfs25M-EPA | AS01 | NCT02942277 |
EPA, ExoProtein A; VLP, Virus Like Particle.