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. 2024 Feb 25;11(17):2309032. doi: 10.1002/advs.202309032

Figure 9.

Figure 9

FOXO1 and FOXO3 are critical regulons in the DAC. A) pySCENIC analysis revealed FOXO1 and FOXO3 as enriched regulons in the DAC in AF. Relative regulon activity (AUC score) is shown for each regulon for each cluster in a heat map. B) FOXO1 regulon activity visualized in a split UMAP plot of healthy versus diseased AF. The DAC is shown in a black box. C) Functional enrichment analysis using Metascape of the 450 genes part of the FOXO1 regulon. D) FOXO1 skeletal system development (GO:0 001501) gene regulatory network (GRN) as visualized in a Cytoscape plot. E) FOXO3 regulon activity visualized in a split UMAP plot of healthy versus diseased AF. The stem cell subset and the DAC are shown in black boxes. F) Functional enrichment analysis using Metascape of the 89 genes part of the FOXO3 regulon. G) FOXO3 GRN as visualized in a Cytoscape plot.