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. 2024 May 8;43:138. doi: 10.1186/s13046-024-03060-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — HRH1 expression in PDAC correlates with low HLA-ABC expression, CD8 T cell infiltration, and poor survival in human PDAC. A HRH1 mRNA expression in normal pancreatic tissue, adjacent non-tumor tissue, and PDAC tissue in public data. B Representative images of immunohistochemical (IHC) for HRH1 in normal pancreas and PDAC. The blue arrow indicates a normal duct. The red arrow indicates PDAC cells. Quantification of HRH1 expression intensity in normal ducts and paired tumor cells, n = 20. C Kaplan–Meier analysis of overall survival according to HRH1 expression by R2: Genomics Analysis and Visualization Platform. D The correlation plot of the mRNA relationships between HRH1 and CD3D⁺/CD45⁺ and CD8A⁺/CD45⁺, respectively (public data: CRA001160). E The correlation plot of the mRNA relationships between HRH1 and T cell exhaustion scores using GEPIA 2.0. F Representative images of IHC for HRH1, HLA-ABC, CD8, and GZMB in human PDAC tissues. The red arrow indicates GZMB. G The relationship between HRH1 protein levels and CD8, HLA-ABC, or GZMB protein levels in human PDAC tissues, n = 43. Scale bar = 100 µm (B, F). Median (A, B); *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. HRH1, histamine receptor H1; PDAC, Pancreatic ductal adenocarcinoma; GZMB, Granzyme B