Title {1}	Personalized Mechanical Ventilation Guided by UltraSound in Patients with Acute Respiratory Distress Syndrome (PEGASUS): study protocol for an international randomized clinical trial.
Trial registration {2a and 2b}.	https://clinicaltrials.gov, ID: NCT05492344
Protocol version {3}	Protocol version 4.0, date 02–11-2022
Funding {4}	Funding from the Amsterdam UMC.
Author details {5a}	* Correspondence: Jante S. Sinnige, j.s.sinnige@amsterdamumc.nl. 1 Department of Intensive Care, Amsterdam University Medical Centres (UMC), University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. 2 Department of Medicine, Chattogram Medical Centre, Chattogram, Bangladesh. 3 Department of Intensive Care, Amsterdam UMC, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands. 4 Department of anesthesiology and intensive care, Copenhagen University Hospital—Bispebjerg and Frederiksberg, Copenhagen, Denmark. 5 Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. 6 First Department of Intensive Care Medicine, University of Athens Medical School, 10,676 AZ Athens, Greece. 7 Anaesthesia and Intensive Care Medicine, Galway University Hospitals and School of Medicine, University of Galway, H91 TK33, Ireland. 8 NOVA Medical School, CHRC, NOVA University of Lisbon, Portugal. 9 Center for Clinical Epidemiology and Research Unit of Clinical Epidemiology, OUH Odense University Hospital, Denmark. 10 Department of Intensive Care, Hospital de São Francisco Xavier, CHLO, Lisbon, Portugal. 11 Department of Intensive Care, Brugmann University Hospital, Université Libre de Bruxelles,1050 Brussels, Belgium. 12 Department of Precision-Regenerative Medicine and Jonic Area (DiMePRe-J), Section of Anesthesiology and Intensive Care Medicine, University of Bari "Aldo Moro", Bari, Italy. 13 Servei de Medicina Intensiva, Parc Taulí Hospital Universitari, Institut de Recerca Part Taulí (I3PT-CERCA), Parc del Taulí 1, 08028 Sabadell, Spain. 14 Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. 15 Mahidol Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Bangkok 10,400, Thailand. 16 Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK. 17 Department of Anaesthesiology and Intensive Care, National Institute of Medicine of the Ministry of Interior and Administration, 02–507 Warsaw, Poland. 18 Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, Netherlands 19 Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70,124 Bari, Italy. 20 Department of Pulmonology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. 21 Laboratory of Experimental Intensive Care and Anaesthesiology (L.E.I.C.A.), University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Name and contact information for the trial sponsor {5b}	Dr. Lieuwe D. J. Bos Department of Intensive Care Amsterdam University Medical Centers Meibergdreef 9 1105 AZ Amsterdam The Netherlands Email address: l.d.bos@amsterdamumc.nl
Role of sponsor {5c}	The sponsor is responsible for the study design, overseeing data collection, management of sites, analysis and interpretation of data, writing of the report, and the decision to submit the report for publication.