Figure 2.

Geometric mean plasma concentrations of selumetinib versus time—multiple dose (A. Linear; B. Semi-logarithmic).^a

^aClinically implausible high concentrations of selumetinib were reported for 3 participants at 12 h post-dose in the fasted treatment period. The plasma concentration–time profiles for each participant from the last timepoint with a measurable concentration (8 h) to 12 h post-dose to estimate the AUC_0–12,SS values were extrapolated. As the percentage extrapolation was small, and to maximize the data used in the statistical assessment of food effect, the AUC_0–12,ss values for these 3 participants' T2 selumetinib profiles were considered to be representative of the primary endpoint parameter and, therefore, were included in the statistical analysis. AUC_0–12,ss, area under the concentration–time curve from time zero to 12 h at steady state.