FIG. 1:

The kinetics of an immune response. The first peak signified by “innate” indicates the response of tissue macrophages and immature dendritic cells, which mature over the first few days following microbial (or antigenic) challenge to ferry antigen to local draining lymph nodes. Both also secrete innate cytokines and chemokines to recruit neutrophils. These sensory innate responses are integrated by innate-like effector lymphocytes, whose activities peak after the innate immune response, and relay context to the adaptive immune system T and B cells, impacting the antigenic burden.