FIGURE 2.

Gentamicin pharmacokinetic model prediction error during all phases of controlled TH, encompassing the hypothermic, normothermic, and combined phases. Prediction error is assessed through bias, represented by (A) mean prediction error in mg/L, and precision, illustrated by (B) RMSE in mg/L. Closed circles denote the mean values with accompanying 95% confidence intervals. Low levels indicate gentamicin concentrations ≤1.5 mg/L, and high levels represent gentamicin concentrations between 0 and 2 hours after dosing. Prediction error for high levels during the normothermic phase is not presented because of the limited number of samples during this phase.