TABLE 1.

Patient Characteristics and Samples Drawn

Characteristic*	Model-Building Data Set	External Data Set
Subjects (n)	47	39
Male, n (%)	27 (58.7)	22 (56.4)
Birth weight, grams	3400 (2090–5070)	3170 (2260–4620)
GA, wks†	40 (36–42)	40 (36–42)
PNA, d‡	4.7 (2.3–5.2)	3.1 (1.5–4.9)
SCr (µmol/L)§	49 (26–114)	73 (29–167)
Urine output (mL/kg/h)	3.0 (0.1–7.6)	2.5 (0.01–7.1)
Thompson score†	9 (3–19)	9 (6–15)
MOF, n (%)§	19 (40.4%)	13 (33.3%)
Duration gentamicin treatment, d¶	2 (0–5)	1.5 (0–4)
Daily gentamicin dose (mg/kg)	4.0 (3.5–5.1)	4.0 (3.0–5.9)
Total number of samples
During study period	612	323
Per patient during study period*	14 (4–16)	8 (2–15)
During hypothermic phase (%)	386 (63)	258 (80)
Per patient during hypothermic phase*	9 (3–9)	7 (2–9)
During normothermic phase (%)	219 (36)	65 (20)
Per patient during normothermic phase*	6 (0–6)	1 (0–6)

^*Baseline characteristics are depicted by median and range for continuous variables and percentages for categorical variables.

^†Measured at admittance.

^‡Measured at the end of the study period.

^§Measured throughout the study period.

^¶Gentamicin treatment duration of 0 days indicates that a single dose was administered.

MOF, multiorgan failure; PNA, postnatal age; SCr, serum creatinine.