Table 1.
Description of Included Studies of Children with 22qDS with Preoperative Imaging and Controls without 22qDS
| Author (Year) | OLE | Study Design | Total 22qDS Patients (N) | Patient Age Mean, Year (Range) | Patient Male (%) | Patients with Imaging (N) | ICA Anomaly (N) | ICA Medialization (N) | Completed surgery (N) | Total Controls (N) | Controls, ICA Medialization (N) | Type of imaging used | Recommends universal preoperative imaging? (Yes/No) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Álvarez Carvajal (2018) | 4 | CS | 8 | 9.25 (4-17) | 75.0 | 8 | 2 | 2 | 8 | 0 | NA | CTA | Y |
| Baek (2013) | 3b | CC | 23 | 9.7 (NR) | 60.9 | 23 | 10 | 10 | 23 | 21 | 3 | MRA* | N |
| Bois (2017) | 4 | CS | 9 | 7 (4-11) | 55.6 | 9 | 9 | 9 | 9 | 0 | NA | MRA or CTA | Y |
| Fallico (2020) | 4 | CS | 40 | NR (NR) | 47.5 | 23 | 7 | 7 | NR | 0 | NA | MRA | Y |
| Kimia (2020) | 4 | CS | 90 | 7.34 (0.85-17.2) | 47.8 | 90 | 29 | 23 | NR | 0 | NA | MRA | Y |
| Lai (2004) | 4 | CS | 7 | 6.9 (3-11) | 42.9 | 7 | 5 | 3 | 6 | 0 | NA | MRA and/or CTA | Y |
| Mitnick (1996) | 4 | CS | 20 | NR (3-32) | 45.0 | 20 | 13 | 12 | 15 | 0 | NA | MRA | Y |
| Oppenheimer (2010) | 3b | CC | 86 | 8 (3-24) | 53.5 | 86 | NR | 42 | NR | 50 | 5 | MRA | Y |
| Ross (1996) | 3b | CC | 25 | 7.6 (4.5-14.1) | 56.0 | 25 | 25 | 25 | NR | 5 | 0 | CTA | N |
| Stransky (2015) | 4 | CS | 70 | 6.9 (3-16) | 48.6 | 70 | 38 | 10 | 69 | 0 | NA | MRA or CTA | Y |
| Tatum (2002) | 4 | CS | 20 | 6.2 (4-17) | 55.0 | 20 | 20 | 13 | 20 | 0 | NA | MRA or CTA | Y |
CC = case-control; CS = case series; CTA = Computed Tomography Angiography; ICA = Internal Carotid Artery; OLE = Oxford Level of Evidence; N = number of participants; NA = not applicable; NR = not reported; MRA = Magnetic Resonance Angiogram; 22qDS = 22q11 Deletion Syndrome;
*
n=1 underwent CTA because imaging was originally to evaluate levator veli palatini muscle hypoplasia