Extended Data Fig. 4. Cells with high levels of missense heteroplasmy have a growth disadvantage in standard cell culture conditions.

Population doublings per day (a) and cumulative cell counts (b) in LHON- and SILENT-edited high heteroplasmic cells. In b, numbers reflect the fraction of total LHON-edited cells vs SILENT-edited cells. Data for n = 3 independent biological replicates are shown. Error bars reflect the mean ± s.d. *P ≤ 0.05; ***P ≤ 0.001; ns > 0.05; by Student’s unpaired two-tailed t-test.