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. 2024 Apr 24;629(8011):443–449. doi: 10.1038/s41586-024-07350-y

Extended Data Fig. 5. Time course of WRN degradation and DNA damage induction after HRO761 treatment.

Extended Data Fig. 5

Immunoblots for WRN, pATM (S1981), pCHK2 (T68), total CHK2, phospho-KAP1 (S824), pCHK1 (S345), total CHK1, pATR (Y1989), p21, γH2AX and actin during 0.25 h to 24 h of treatment of HCT116 cells with HRO761 at the concentrations indicated. Images from a representative experiment of n = 3.