Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Single-strand gaps are the targets for C-terminal binding, but inhibit the core domain interaction with DNA. As labelled probes the following dsDNA oligonucleotides were used: BC, containing the p53 binding site, negative control MNGC and gap-containing MNG1 and MNG2 (1 and 2 nt gaps, respectively). Complex IV formed via the p53 core domain induced by PAb421 is indicated by an arrow. Faster migrating complexes between the p53 C-terminus and MNG2 are indicated with a bracket.
