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. 2024 May 9;14:10616. doi: 10.1038/s41598-024-61125-z

Figure 2.

Figure 2

Chaga mushroom extract inhibits the cell cycle in oral cancer cells via downregulation of p-STAT3. (A) Flow cytometry analysis on the cell cycle in HSC-4 cells after treatment (0, 160, 200, 400, and 800 μg/mL). (B) Quantification of G0/G1 phase in HSC-4 cells after treatment. (C) Quantification of the S phase in HSC-4 cells after treatment (0, 160, 200, 400, and 800 μg/mL). (D) Expression level of phosphorylated STAT3 (p-STAT3) and total STAT3 (STAT3) in HSC-4 cells after treatment (200 μg/mL) for the indicated time points (0, 15, 30, 60, and 120 min). Values represent the mean ± SEM. **p < 0.01 vs. untreated HSC-4 cells.