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. 2024 May 8;15:3882. doi: 10.1038/s41467-024-48073-y

Fig. 4. IFN pathway activation is a positive predictor of survival after ATL-DC vaccine and TLR agonist therapy.

Fig. 4

A Kaplan-Meier progression-free survival curves of all patients (left), GBM (center), and Grade III glioma subsets (right) stratified by their HALLMARK_INTERFERON_GAMMA_RESPONSE GSVA scores in their post-treatment PBMCs. P values, log-rank test. B, C Multivariate Cox proportional hazards analysis assessing hazard ratios of tumor progression in patients with high HALLMARK_INTERFERON_GAMMA_RESPONSE GSVA score in all patients (B) or GBM subset (C) after adjusting for other clinical covariates. In the forest plot, the squares are the hazard ratio (HR) estimates, the error bars are 95% confidence interval (CI) of the HR, the P value of each covariate is based on its Wald statistics, the P values are not adjusted. In B, the sample distribution in each covariate is GSVA score (post-Tx): <median=10, ≥median=11; Grade: III = 7, IV = 14; MGMT_methylation: True=7, False=14. In (C), GSVA score (post-Tx): <median=7, ≥median=7; MGMT_methylation: True=3, False=11.