Fig. 6. Simulated AUC of primaquine from the mother-to-infant model using different dosing regimens (n = 1000).
a 0.5 mg base/kg once daily for 14 days. b 1 mg base/kg once daily for 7 days. c 0.5 mg base/kg twice daily for 7 days. d 0.25 mg base/kg single dose. The solid black lines represent the median of the simulations in infants. The blue shaded areas represent the 95% prediction intervals of the simulations in infants. The red shaded areas represent the 95% prediction interval of the simulated AUC in the mothers with 60 kg body weight. The red solid lines represent the median AUC0-24h (512 ng × h/mL) of the mother receiving single low dose of primaquine (0.25 mg base/kg), a reference for a primaquine exposure known not to cause significant haemolysis in G6PD deficient individuals.