Table 3.

Toxicity parameters prediction of the lead compounds.

Parameters		3′-Hydroxy-alpha-naphthoflavone	3′-Hydroxy-ss-naphthoflavone	Genkwanin	Apigenin	Ro 61-8048
LD50(mg/kg)		2500	4000	3919	2500	4500
Prediction class		Class V	Class V	Class V	Class V	Class V
Hepatotoxicity	Prediction	Inactive	Inactive	Inactive	Inactive	Active
	Probability	0.65	0.63	0.72	0.68	0.61
Carcinogenicity	Prediction	Inactive	Active	Active	Inactive	Active
	Probability	0.50	0.56	0.51	0.62	0.56
Immunotoxicity	Prediction	Inactive	Inactive	Inactive	Inactive	Inactive
	Probability	0.94	0.85	0.95	0.99	0.98
Mutagenicity	Prediction	Inactive	Inactive	Active	Inactive	Active
	Probability	0.60	0.62	0.57	0.57	0.52
Prediction accuracy		69.26 %	70.97 %	70.97 %	70.97 %	67.38 %