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KMO inhibition (IC50) by the lead compounds.
| Compound | IC50 (μM) | Inhibition type |
|---|---|---|
| 3′-Hydroxy-alpha-naphthoflavone | 15.85 ± 0.98 | Competitive |
| 3′-Hydroxy-ss-naphthoflavone | 18.71 ± 0.78 | Competitive |
| Genkwanin | 21.61 ± 0.97 | Non-competitive |
| Apigenin | 24.14 ± 1.00 | Non-competitive |
| Ro 61–8048 (positive control) | 4.96 ± 0.31 | NT (not tested) |
