Table 2.
Univariate and multivariable Cox analyses for bladder recurrence.
| Study variables | Univariate | Multivariable | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-Value | aHR | 95% CI | p-Value | |
| IO vs. PO | 0.19 | 0.04–0.86 | 0.031 | 0.15 | 0.03–0.81 | 0 . 028 |
| Age, years | 1.06 | 0.99–1.15 | 0.117 | 1.05 | 0.95–1.15 | 0.352 |
| Sex (male vs. female) | 1.10 | 0.35–3.45 | 0.876 | |||
| ASA (3 vs. 2) | 0.96 | 0.26–3.55 | 0.951 | |||
| Hospital stay, day | 0.92 | 0.66–1.29 | 0.636 | |||
| EBL (ml) | 1.00 | 0.99–1.01 | 0.999 | |||
| Margins (positive vs. negative) | 2.11 | 0.57–7.80 | 0.264 | |||
| Sarcomatoid (yes vs. no) | 5.08 | 1.36–18.93 | 0.016 | 10.25 | 2.14–49.19 | 0 . 004 |
| Concomitant CIS (yes vs. no) | 1.27 | 0.38–4.21 | 0.699 | |||
| pT (vs. T0/Tis/Ta) | ||||||
| T1/T2 | 0.57 | 0.08–4.07 | 0.579 | |||
| T3/T4 | 1.93 | 0.41–9.10 | 0.405 | |||
| pGrade (high vs. low) | 0.90 | 0.12–6.95 | 0.917 | |||
| Multifocal (yes vs. no) | 2.61 | 0.83–8.24 | 0.101 | 3.90 | 0.91–16.77 | 0.067 |
| LVI (yes vs. no) | 2.28 | 0.50–10.43 | 0.287 | |||
| PNI (yes vs. no) | 7.68 | 1.61–36.54 | 0.010 | 4.50 | 0.75–27.07 | 0.100 |
| Lymph node dissection (yes vs. no) | 0.98 | 0.260–3.60 | 0.970 | |||
MMC, mitomycin-C; IO, intraoperative MMC instillation; PO, postoperative MMC instillation (at least 24 h after surgery); ASA, American Society of Anesthesiologists; EBL, estimated blood loss; CIS, carcinoma in situ; LVI, lymph vascular invasion; PNI, perineural invasion; NA, no event occurred in a classified subgroup; HR, hazard ratio; aHR, adjusted hazard ratio; CI, confidence interval.
p-value < 0.05 is shown in bold.
Variables with p-value <0.2 in the univariate analysis were adjusted for in the multivariable analysis.