TABLE 1.
Summary of drug classes involved in cannabis–drug interactions.
| Drug classes | Number of studies | Probability | Severity | |||||
|---|---|---|---|---|---|---|---|---|
| Possible | Probable | Defined | Minor | Moderate | Severe | N/A | ||
| Antiepileptics | 14 | 2 | 12 | 3 | 2 | 9 | ||
| Benzodiazepines | 8 | 1 | 7 | 3 | 1 | 4 | ||
| Opioids | 4 | 4 | 1 | 3 | ||||
| Calcineurin inhibitors | 3 | 3 | 1 | 2 | ||||
| Anticoagulants | 2 | 2 | 2 | |||||
| Antiretrovirals | 2 | 2 | 2 | |||||
| Barbiturates | 2 | 2 | 1 | 1 | ||||
| Mechanistic target of rapamycin (mTOR) inhibitors | 2 | 2 | 1 | 1 | ||||
| Xanthines | 2 | 2 | 2 | |||||
| Alkylating agents | 1 | 1 | 1 | |||||
| Antibiotics | 1 | 1 | 1 | |||||
| Antifungals | 1 | 1 | 1 | |||||
| Proton pump inhibitors (PPIs) | 1 | 1 | 1 | |||||
| Selective serotonin reuptake inhibitors (SSRIs) | 1 | 1 | 1 | |||||
| Taxanes | 1 | 1 | 1 | |||||
| Topoisomerase I inhibitors | 1 | 1 | 1 | |||||
| Psychostimulants | 1 | 1 | 1 | |||||
| Cannabis (THC) | 1 | 1 | 1 | |||||
| Cardiovascular system treatments (not specified) | 1 | 1 | 1 | |||||
| Diuretics | 1 | 1 | 1 | |||||
| Laxatives | 1 | 1 | 1 | |||||