Figure 2.

Effects of delayed sedation with propofol or dexmedetomidine starting at 60 minutes after return of spontaneous circulation. (A) Percent survival in the first 10 days after cardiac arrest. Ten male mice per group. (B) Neurological function scores at 5 days after cardiac arrest that were assessed using the Scale 1. Ten male mice per group. Note that dead mice (scored at 0 points) were included in the statistical analysis. (C) Changes in the relative cerebral blood flow in the first 240 minutes after return of spontaneous circulation in male mice without sedation and those sedated with propofol or dexmedetomidine starting at 60 minutes after return of spontaneous circulation. Data are presented as mean ± SD. A two-way repeated measures ANOVA with the post hoc Dunnett’s test was performed during and after the period of sedation (two-way repeated measures ANOVA, propofol vs. no sedation, interaction effect [group × time]: P = 0.011; dexmedetomidine vs. no sedation, interaction effect [group × time]: P = 0.074, main effect: P = 0.202). The colored line below indicates statistically significant differences from the no sedation group at specific time points after resuscitation (P < 0.05; red: dexmedetomidine vs. no sedation; Dunnett’s test).