Table 1. Demographics and clinical findings for MTX-LPD.
| MTX-LPD (n = 48) | |||
|---|---|---|---|
| DLBCL type (n = 24) | CHL type (n = 24) | P | |
| Age, mean (range) | 76.1 (62–87) | 66.8 (41–82) | 0.002* |
| Sex (male:female) | 3:21 | 8:16 | 0.084 |
| Underlying condition n (%) | |||
| Rheumatoid arthritis | 21 (87.5) | 20 (83.3) | ― |
| Hashimoto disease | 1 (4.2) | 0 | ― |
| SAPHO syndrome | 0 | 1 (4.2) | ― |
| Crohn disease | 0 | 1 (4.2) | ― |
| Unknown | 3 (12.5) | 2 (8.3) | ― |
| Excised or biopsied site n (%) | |||
| Lymph nodes | 15 (62.5) | 23 (95.8) | ― |
| Axillary | 6 (25.0) | 3 (12.5) | ― |
| Cervical | 4 (16.7) | 8 (33.3) | ― |
| Subclavicular | 0 | 3 (12.5) | ― |
| Mediastinal | 0 | 1 (4.2) | ― |
| Inguinal | 3 (12.5) | 4 (16.7) | ― |
| Peribronchial | 1 (4.2) | 0 | ― |
| Retroperitoneum | 0 | 3 (12.5) | ― |
| LN of unknown site | 1 (4.2) | 1 (4.2) | ― |
| Soft tissue | 2 (8.3) | 0 | ― |
| Skin | 2 (8.3) | 0 | ― |
| Stomach | 2 (8.3) | 0 | ― |
| Tonsil | 1 (4.2) | 0 | ― |
| Gingiva | 1 (4.2) | 0 | ― |
| Orbit | 1 (4.2) | 0 | ― |
| Liver | 0 | 1 (4.2) | ― |
| Presence of EBV infection† | |||
| Present | 15 (62.5) | 22 (91.7) | 0.011* |
| Absent | 8 (33.3) | 1 (4.2) | |
†The presence of EBV infection was evaluated by EBER in situ hybridization or LMP-1 immunostaining in proliferating atypical lymphocytes, and 23 cases each of DLBCL type and CHL type were evaluated. Significance was calculated using the Mann–Whitney U test. Fisher’s exact analysis was used for the statistical analysis of nominal scales. *P < 0.05.