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. 2024 May 9;17:15. doi: 10.1186/s13072-024-00540-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Diagram shows that UHRF1 is a junction protein involved in signal transduction. UHRF1 participates in signal transduction by interacting with different proteins. A: The UHFR1-BRCA1 interaction regulates DNA damage response; B: The N-terminal binding of YAP1 and UHRF1 promotes cell proliferation; C: The PARP1 and UHRF1 SRA domain binding complex inhibits gene transcription activity; D: The interaction between PP2A and UHRF1 SRA domain affects the activity of AMPK. YAP1: Yes-associated protein 1; DNMT1: DNA (cytosine-5)-methyltransferase 1; PARP1: Poly (ADP-ribose) Polymerase 1; PP2A: Protein Phosphatase 2A; AMPK: AMP-activated protein kinase; BRCA1: Breast Cancer susceptibility gene 1